| Gene | Nucleotide Mutations | Amino Acid Changes |
|---|---|---|
| ORF1ab | C3266T, T6953C, C5387A, 11288:11296 deletion | T1001I, I2230T, A1708D |
| S | A23062T, C23270A, A23402G, C23603A, C23708T, T24505G, G24913C | DEL69-70, DEL144Y, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H |
| N | GAT28279CTA, C28976T | D3L, S235F |
| ORF8 | G28047T, C27971T, A28110G | R52I, Q27_, Y73C |
As figure 3.2 indicates, the majority of B.1.1.7 genomes identified in the US to-date were identified by S-gene target failures (SGTF)
in community-based diagnostic PCR testing.
SGTF indicates a deletion mutation that is one of several mutations able to distinguish the B.1.1.7 from other SARS-CoV-2 strains.
This tells us the lineage is present in the US. However, since this was not an unbiased sampling approach,
it does not indicate the true prevalence of the B117 lineage in the US.
Estimates of true prevalence in the US are discussed here.